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Welcome to the Tsai Lab

Selected recent publications:

1. Cunningham, C.N., Williams, J.M., Knupp, J., Arunagiri, A., Arvan, P*., and Tsai, B*. (2019). Cells deploy a two-pronged strategy to rectify misfolded proinsulin aggregates. Molecular Cell (pii: S1097-2765 (19) 30364-8). *co-corresponding authors

2. Lin, D.L., Inoue, T., Chen, Y-J., Chang, A, Tsai, B*., and Tai, A.W*. (2019). The ER Membrane Protein Complex promotes biogenesis of dengue and Zika virus non-structural multi-pass transmembrane proteins to support virus infection. Cell Reports, 27, 1666-1674. *co-corresponding authors

3. Inoue, T., Zhang, P., Zhang, W., Goodner-Bingham, K., Dupzyk, A., DiMaio, D*., Tsai, B*. (2018). g-secretase promotes membrane insertion of the human papillomavirus L2 capsid protein during virus infection. J. Cell Biology, 217, 3545-3559. *co-corresponding authors

4. Inoue, T., and Tsai, B. (2017). Regulated Erlin-dependent release of the B12 transmembrane J-protein promotes ER membrane penetration of a non-enveloped virus. PLoS Pathogen 13, e1006439.

5. Ravindran, M.S., Engelke, M.F., Verhey, K.J., and Tsai, B. (2017). Exploiting the kinesin-1 molecular motor to generate a virus membrane penetration site. Nature Communications 8, 15496.

6. Bagchi, P., Inoue, T., and Tsai, B. (2016). EMC1-dependent stabilization drives membrane penetration of a partially destabilized non-enveloped virus. eLife pii: e21470.