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Welcome to the Tsai Lab

Selected recent publications:

1.    Spriggs, C.C., Badieyan, S., Verhey, K.J., Cianfrocco, M.A.*, and Tsai, B*. (2020). Golgi-associated BICD adaptors couple ER membrane penetration and disassembly of a viral cargo. Journal of Cell Biology 219, pii: e201908099. *co-corresponding authors

2.   Bagchi, P*., Torres, M., Qi, L., and Tsai, B*. (2020). Selective EMC subunits act as molecular tethers of intracellular organelles exploited during viral entry. Nature Communications 11, 1127. *co-corresponding authors

 3.   Chen, Y-J., Williams, J. M., Arvan, P., and Tsai, B. (2020). Reticulon protects the integrity of the ER membrane during ER escape of large macromolecular protein complexes. Journal of Cell Biology 219, pii: e201908182.

 4.   Cunningham, C.N., Williams, J.M., Knoop, J., Arunagiri, A., Arvan, P*., and Tsai, B*. (2019). Cells deploy a two-pronged strategy to rectify misfolded proinsulin aggregates. Molecular Cell 75, 442-456 *co-corresponding authors

 5.   Lin, D.L., Inoue, T., Chen, Y-J., Chang, A, Tsai, B*., and Tai, A.W*. (2019). The ER Membrane Protein Complex promotes biogenesis of dengue and Zika virus non-structural multi-pass transmembrane proteins to support virus infection. Cell Reports, 27, 1666-1674. *co-corresponding authors

 6.   Inoue, T., Zhang, P., Zhang, W., Goodner-Bingham, K., Dupzyk, A., DiMaio, D*., Tsai, B*. (2018). -secretase promotes membrane insertion of the human papillomavirus L2 capsid protein during virus infection. Journal of Cell Biology, 217, 3545-3559. *co-corresponding authors

7.   Inoue, T*., and Tsai, B*. (2017). Regulated Erlin-dependent release of the B12 transmembrane J-protein promotes ER membrane penetration of a non-enveloped virus. PLoS Pathogens 13, e1006439. *co-corresponding authors 

8.   Ravindran, M.S., Engelke, M.F., Verhey, K.J., and Tsai, B. (2017). Exploiting the kinesin-1molecular motor to generate a virus membrane penetration site. Nature Communications 8, 15496.

9.   Bagchi, P., Inoue, T., and Tsai, B. (2016). EMC1-dependent stabilization drives membrane penetration of a partially destabilized non-enveloped virus. eLife pii: e21470.

 10. Ravindran, M.S., Bagchi, P., Inoue, T., and Tsai, B. (2015). A non-enveloped virus hijacks host disaggregation machinery to translocate across the endoplasmic reticulum membrane. PLoS Pathogens 11, e1005086. 

11. Walczak, C.P., Ravindran, M.S., Inoue, T., and Tsai, B. (2014). A cytosolic chaperone complexes with dynamic membrane J-proteins and mobilizes a nonenveloped virus out of the endoplasmic reticulum. PLoS Pathogens 10, e1004007.