Publications

Complete List of Published Work:

http://www.ncbi.nlm.nih.gov/sites/myncbi/billy.tsai.1/bibliography/44565086/public/?sort=date&direction=descending

1.     Arunagiri A, Haataja L, Pottekat A, Pamenan F, Kim S, Zeltser LM, Paton AW, Paton JC, Tsai B, Itkin-Ansari P, Kaufman RJ, Liu M, Arvan P. Proinsulin misfolding is an early event in the progression to type 2 diabetes. Elife. 2019 Jun 11;8. doi: 10.7554/eLife.44532. PubMed PMID: 31184302; PubMed Central PMCID: PMC6559786.

2.     Cunningham CN, Williams JM, Knupp J, Arunagiri A, Arvan P, Tsai B. Cells Deploy a Two-Pronged Strategy to Rectify Misfolded Proinsulin Aggregates. Mol Cell. 2019 May 29;. doi: 10.1016/j.molcel.2019.05.011. [Epub ahead of print] PubMed PMID: 31176671; NIHMSID:NIHMS1529576.

3.     Lin DL, Inoue T, Chen YJ, Chang A, Tsai B, Tai AW. The ER Membrane Protein Complex Promotes Biogenesis of Dengue and Zika Virus Non-structural Multi-pass Transmembrane Proteins to Support Infection. Cell Rep. 2019 May 7;27(6):1666-1674.e4. doi: 10.1016/j.celrep.2019.04.051. PubMed PMID: 31067454; PubMed Central PMCID: PMC6521869.

4.     Inoue T, Zhang P, Zhang W, Goodner-Bingham K, Dupzyk A, DiMaio D, Tsai B. γ-Secretase promotes membrane insertion of the human papillomavirus L2 capsid protein during virus infection. J Cell Biol. 2018 Oct 1;217(10):3545-3559. doi: 10.1083/jcb.201804171. Epub 2018 Jul 13. PubMed PMID: 30006461; PubMed Central PMCID: PMC6168257.

5.     Dupzyk A, Tsai B. Bag2 Is a Component of a Cytosolic Extraction Machinery That Promotes Membrane Penetration of a Nonenveloped Virus. J Virol. 2018 Aug 1;92(15). doi: 10.1128/JVI.00607-18. Print 2018 Aug 1. PubMed PMID: 29769335; PubMed Central PMCID: PMC6052292.

6.     Ravindran MS, Spriggs CC, Verhey KJ, Tsai B. Dynein Engages and Disassembles Cytosol-Localized Simian Virus 40 To Promote Infection. J Virol. 2018 Jun 15;92(12). doi: 10.1128/JVI.00353-18. Print 2018 Jun 15. PubMed PMID: 29593037; PubMed Central PMCID: PMC5974495.

7.     Arunagiri A, Haataja L, Cunningham CN, Shrestha N, Tsai B, Qi L, Liu M, Arvan P. Misfolded proinsulin in the endoplasmic reticulum during development of beta cell failure in diabetes. Ann N Y Acad Sci. 2018 Apr;1418(1):5-19. doi: 10.1111/nyas.13531. Epub 2018 Jan 28. Review. PubMed PMID: 29377149; PubMed Central PMCID: PMC5934315.

8.     Dupzyk A, Williams JM, Bagchi P, Inoue T, Tsai B. SGTA-Dependent Regulation of Hsc70 Promotes Cytosol Entry of Simian Virus 40 from the Endoplasmic Reticulum. J Virol. 2017 Jun 15;91(12). doi: 10.1128/JVI.00232-17. Print 2017 Jun 15. PubMed PMID: 28356524; PubMed Central PMCID: PMC5446632.

9.     Inoue T, Tsai B. Regulated Erlin-dependent release of the B12 transmembrane J-protein promotes ER membrane penetration of a non-enveloped virus. PLoS Pathog. 2017 Jun;13(6):e1006439. doi: 10.1371/journal.ppat.1006439. eCollection 2017 Jun. PubMed PMID: 28614383; PubMed Central PMCID: PMC5484543.

10.  Qi L, Tsai B, Arvan P. New Insights into the Physiological Role of Endoplasmic Reticulum-Associated Degradation. Trends Cell Biol. 2017 Jun;27(6):430-440. doi: 10.1016/j.tcb.2016.12.002. Epub 2017 Feb 9. Review. PubMed PMID: 28131647; PubMed Central PMCID: PMC5440201.

11.  Ravindran MS, Engelke MF, Verhey KJ, Tsai B. Exploiting the kinesin-1 molecular motor to generate a virus membrane penetration site. Nat Commun. 2017 May 24;8:15496. doi: 10.1038/ncomms15496. PubMed PMID: 28537258; PubMed Central PMCID: PMC5458101.

12.  Cunningham CN, He K, Arunagiri A, Paton AW, Paton JC, Arvan P, Tsai B. Chaperone-Driven Degradation of a Misfolded Proinsulin Mutant in Parallel With Restoration of Wild-Type Insulin Secretion. Diabetes. 2017 Mar;66(3):741-753. doi: 10.2337/db16-1338. Epub 2016 Dec 27. PubMed PMID: 28028074; PubMed Central PMCID: PMC5319713.

13.  Bagchi P, Inoue T, Tsai B. EMC1-dependent stabilization drives membrane penetration of a partially destabilized non-enveloped virus. Elife. 2016 Dec 24;5. doi: 10.7554/eLife.21470. PubMed PMID: 28012275; PubMed Central PMCID: PMC5224922.

14.  Dupzyk A, Tsai B. How Polyomaviruses Exploit the ERAD Machinery to Cause Infection. Viruses. 2016 Aug 29;8(9). doi: 10.3390/v8090242. Review. PubMed PMID: 27589785; PubMed Central PMCID: PMC5035956.

15.  Williams JM, Tsai B. Intracellular trafficking of bacterial toxins. Curr Opin Cell Biol. 2016 Aug;41:51-6. doi: 10.1016/j.ceb.2016.03.019. Epub 2016 Apr 13. Review. PubMed PMID: 27084982; PubMed Central PMCID: PMC4983527.

16.  Ravindran MS, Bagchi P, Cunningham CN, Tsai B. Opportunistic intruders: how viruses orchestrate ER functions to infect cells. Nat Rev Microbiol. 2016 Jul;14(7):407-420. doi: 10.1038/nrmicro.2016.60. Epub 2016 Jun 6. Review. PubMed PMID: 27265768; PubMed Central PMCID: PMC5272919.

17.  Ravindran MS, Tsai B. Correction: Viruses Utilize Cellular Cues in Distinct Combination to Undergo Systematic Priming and Uncoating. PLoS Pathog. 2016 Jun;12(6):e1005712. doi: 10.1371/journal.ppat.1005712. eCollection 2016 Jun. PubMed PMID: 27281031; PubMed Central PMCID: PMC4900604.

18.  Inoue T, Tsai B. The Grp170 nucleotide exchange factor executes a key role during ERAD of cellular misfolded clients. Mol Biol Cell. 2016 May 15;27(10):1650-62. doi: 10.1091/mbc.E16-01-0033. Epub 2016 Mar 30. PubMed PMID: 27030672; PubMed Central PMCID: PMC4865321.

19.  Ravindran MS, Tsai B. Viruses Utilize Cellular Cues in Distinct Combination to Undergo Systematic Priming and Uncoating. PLoS Pathog. 2016 Apr;12(4):e1005467. doi: 10.1371/journal.ppat.1005467. eCollection 2016 Apr. Review. PubMed PMID: 27055025; PubMed Central PMCID: PMC4824415.

20.  Haataja L, Manickam N, Soliman A, Tsai B, Liu M, Arvan P. Disulfide Mispairing During Proinsulin Folding in the Endoplasmic Reticulum. Diabetes. 2016 Apr;65(4):1050-60. doi: 10.2337/db15-1345. Epub 2016 Jan 28. PubMed PMID: 26822090; PubMed Central PMCID: PMC4806660.

21.  Sun S, Shi G, Sha H, Ji Y, Han X, Shu X, Ma H, Inoue T, Gao B, Kim H, Bu P, Guber RD, Shen X, Lee AH, Iwawaki T, Paton AW, Paton JC, Fang D, Tsai B, Yates JR 3rd, Wu H, Kersten S, Long Q, Duhamel GE, Simpson KW, Qi L. IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation. Nat Cell Biol. 2015 Dec;17(12):1546-55. doi: 10.1038/ncb3266. Epub 2015 Nov 9. PubMed PMID: 26551274; PubMed Central PMCID: PMC4670240.

22.  He K, Cunningham CN, Manickam N, Liu M, Arvan P, Tsai B. PDI reductase acts on Akita mutant proinsulin to initiate retrotranslocation along the Hrd1/Sel1L-p97 axis. Mol Biol Cell. 2015 Oct 1;26(19):3413-23. doi: 10.1091/mbc.E15-01-0034. Epub 2015 Aug 12. PubMed PMID: 26269577; PubMed Central PMCID: PMC4591687.

23.  He K, Ravindran MS, Tsai B. A bacterial toxin and a nonenveloped virus hijack ER-to-cytosol membrane translocation pathways to cause disease. Crit Rev Biochem Mol Biol. 2015;50(6):477-88. doi: 10.3109/10409238.2015.1085826. Epub 2015 Sep 11. Review. PubMed PMID: 26362261; PubMed Central PMCID: PMC4864032.

24.  Inoue T, Dosey A, Herbstman JF, Ravindran MS, Skiniotis G, Tsai B. ERdj5 Reductase Cooperates with Protein Disulfide Isomerase To Promote Simian Virus 40 Endoplasmic Reticulum Membrane Translocation. J Virol. 2015 Sep;89(17):8897-908. doi: 10.1128/JVI.00941-15. Epub 2015 Jun 17. PubMed PMID: 26085143; PubMed Central PMCID: PMC4524074.

25.  Ravindran MS, Bagchi P, Inoue T, Tsai B. A Non-enveloped Virus Hijacks Host Disaggregation Machinery to Translocate across the Endoplasmic Reticulum Membrane. PLoS Pathog. 2015 Aug;11(8):e1005086. doi: 10.1371/journal.ppat.1005086. eCollection 2015 Aug. PubMed PMID: 26244546; PubMed Central PMCID: PMC4526233.

26.  Williams JM, Inoue T, Chen G, Tsai B. The nucleotide exchange factors Grp170 and Sil1 induce cholera toxin release from BiP to enable retrotranslocation. Mol Biol Cell. 2015 Jun 15;26(12):2181-9. doi: 10.1091/mbc.E15-01-0014. Epub 2015 Apr 15. PubMed PMID: 25877869; PubMed Central PMCID: PMC4462937.

27.  Inoue T, Tsai B. A nucleotide exchange factor promotes endoplasmic reticulum-to-cytosol membrane penetration of the nonenveloped virus simian virus 40. J Virol. 2015 Apr;89(8):4069-79. doi: 10.1128/JVI.03552-14. Epub 2015 Feb 4. PubMed PMID: 25653441; PubMed Central PMCID: PMC4442351.

28.  Bagchi P, Walczak CP, Tsai B. The endoplasmic reticulum membrane J protein C18 executes a distinct role in promoting simian virus 40 membrane penetration. J Virol. 2015 Apr;89(8):4058-68. doi: 10.1128/JVI.03574-14. Epub 2015 Jan 28. PubMed PMID: 25631089; PubMed Central PMCID: PMC4442405.

29.  Walczak CP, Ravindran MS, Inoue T, Tsai B. A cytosolic chaperone complexes with dynamic membrane J-proteins and mobilizes a nonenveloped virus out of the endoplasmic reticulum. PLoS Pathog. 2014 Mar;10(3):e1004007. doi: 10.1371/journal.ppat.1004007. eCollection 2014 Mar. PubMed PMID: 24675744; PubMed Central PMCID: PMC3968126.

30.  Bernardi KM, Williams JM, Inoue T, Schultz A, Tsai B. A deubiquitinase negatively regulates retro-translocation of nonubiquitinated substrates. Mol Biol Cell. 2013 Nov;24(22):3545-56. doi: 10.1091/mbc.E13-06-0332. Epub 2013 Sep 25. PubMed PMID: 24068323; PubMed Central PMCID: PMC3826992.

31.  Moore P, He K, Tsai B. Establishment of an in vitro transport assay that reveals mechanistic differences in cytosolic events controlling cholera toxin and T-cell receptor α retro-translocation. PLoS One. 2013;8(10):e75801. doi: 10.1371/journal.pone.0075801. eCollection 2013. PubMed PMID: 24146777; PubMed Central PMCID: PMC3795749.

32.  Williams JM, Inoue T, Banks L, Tsai B. The ERdj5-Sel1L complex facilitates cholera toxin retrotranslocation. Mol Biol Cell.2013 Mar;24(6):785-95. doi: 10.1091/mbc.E12-07-0522. Epub 2013 Jan 30. PubMed PMID: 23363602; PubMed Central PMCID: PMC3596249.

33.  Inoue T, Tsai B. How viruses use the endoplasmic reticulum for entry, replication, and assembly. Cold Spring Harb Perspect Biol. 2013 Jan 1;5(1):a013250. doi: 10.1101/cshperspect.a013250. Review. PubMed PMID: 23284050; PubMed Central PMCID: PMC3579393.

34.  Walczak CP, Bernardi KM, Tsai B. Endoplasmic reticulum-dependent redox reactions control endoplasmic reticulum-associated degradation and pathogen entry. Antioxid Redox Signal. 2012 Apr 15;16(8):809-18. doi: 10.1089/ars.2011.4425. Epub 2012 Jan 30. Review. PubMed PMID: 22142231; PubMed Central PMCID: PMC3283440.

35.  Goodwin EC, Lipovsky A, Inoue T, Magaldi TG, Edwards AP, Van Goor KE, Paton AW, Paton JC, Atwood WJ, Tsai B, DiMaio D. BiP and multiple DNAJ molecular chaperones in the endoplasmic reticulum are required for efficient simian virus 40 infection. MBio. 2011;2(3):e00101-11. doi: 10.1128/mBio.00101-11. Print 2011. PubMed PMID: 21673190; PubMed Central PMCID: PMC3111607.

36.  Inoue T, Tsai B. A large and intact viral particle penetrates the endoplasmic reticulum membrane to reach the cytosol.PLoS Pathog. 2011 May;7(5):e1002037. doi: 10.1371/journal.ppat.1002037. Epub 2011 May 12. PubMed PMID: 21589906; PubMed Central PMCID: PMC3093372.

37.  Walczak CP, Tsai B. A PDI family network acts distinctly and coordinately with ERp29 to facilitate polyomavirus infection.J Virol. 2011 Mar;85(5):2386-96. doi: 10.1128/JVI.01855-10. Epub 2010 Dec 15. PubMed PMID: 21159867; PubMed Central PMCID: PMC3067762.

38.  Inoue T, Moore P, Tsai B. How viruses and toxins disassemble to enter host cells. Annu Rev Microbiol. 2011;65:287-305. doi: 10.1146/annurev-micro-090110-102855. Review. PubMed PMID: 21682643.

39.  Tsai B, Inoue T. A virus takes an “L” turn to find its receptor. Cell Host Microbe. 2010 Oct 21;8(4):301-2. doi: 10.1016/j.chom.2010.10.003. PubMed PMID: 20951962.

40.  Qian M, Tsai B. Lipids and proteins act in opposing manners to regulate polyomavirus infection. J Virol. 2010 Oct;84(19):9840-52. doi: 10.1128/JVI.01093-10. Epub 2010 Jul 28. PubMed PMID: 20668088; PubMed Central PMCID: PMC2937789.

41.  Moore P, Bernardi KM, Tsai B. The Ero1alpha-PDI redox cycle regulates retro-translocation of cholera toxin. Mol Biol Cell.2010 Apr 1;21(7):1305-13. doi: 10.1091/mbc.e09-09-0826. Epub 2010 Feb 3. PubMed PMID: 20130085; PubMed Central PMCID: PMC2847533.

42.  Tsai B, Qian M. Cellular entry of polyomaviruses. Curr Top Microbiol Immunol. 2010;343:177-94. doi: 10.1007/82_2010_38. Review. PubMed PMID: 20373089.

43.  Bernardi KM, Williams JM, Kikkert M, van Voorden S, Wiertz EJ, Ye Y, Tsai B. The E3 ubiquitin ligases Hrd1 and gp78 bind to and promote cholera toxin retro-translocation. Mol Biol Cell. 2010 Jan 1;21(1):140-51. doi: 10.1091/mbc.e09-07-0586. Epub 2009 Oct 28. PubMed PMID: 19864457; PubMed Central PMCID: PMC2801707.

44.  Erickson KD, Garcea RL, Tsai B. Ganglioside GT1b is a putative host cell receptor for the Merkel cell polyomavirus. J Virol.2009 Oct;83(19):10275-9. doi: 10.1128/JVI.00949-09. Epub 2009 Jul 15. PubMed PMID: 19605473; PubMed Central PMCID: PMC2748031.

45.  Qian M, Cai D, Verhey KJ, Tsai B. A lipid receptor sorts polyomavirus from the endolysosome to the endoplasmic reticulum to cause infection. PLoS Pathog. 2009 Jun;5(6):e1000465. doi: 10.1371/journal.ppat.1000465. Epub 2009 Jun 5. PubMed PMID: 19503604; PubMed Central PMCID: PMC2685006.

46.  Forster ML, Mahn JJ, Tsai B. Generating an unfoldase from thioredoxin-like domains. J Biol Chem. 2009 May 8;284(19):13045-56. doi: 10.1074/jbc.M808352200. Epub 2009 Mar 16. PubMed PMID: 19289469; PubMed Central PMCID: PMC2676037.

47.  Jiang M, Abend JR, Tsai B, Imperiale MJ. Early events during BK virus entry and disassembly. J Virol. 2009 Feb;83(3):1350-8. doi: 10.1128/JVI.02169-08. Epub 2008 Nov 26. PubMed PMID: 19036822; PubMed Central PMCID: PMC2620883.

48.  Rainey-Barger EK, Mkrtchian S, Tsai B. The C-terminal domain of ERp29 mediates polyomavirus binding, unfolding, and infection. J Virol. 2009 Feb;83(3):1483-91. doi: 10.1128/JVI.02057-08. Epub 2008 Nov 19. PubMed PMID: 19019959; PubMed Central PMCID: PMC2620899.

49.  Bernardi KM, Forster ML, Lencer WI, Tsai B. Derlin-1 facilitates the retro-translocation of cholera toxin. Mol Biol Cell. 2008 Mar;19(3):877-84. doi: 10.1091/mbc.e07-08-0755. Epub 2007 Dec 19. PubMed PMID: 18094046; PubMed Central PMCID: PMC2262961.

50.  Lam AD, Tryoen-Toth P, Tsai B, Vitale N, Stuenkel EL. SNARE-catalyzed fusion events are regulated by Syntaxin1A-lipid interactions. Mol Biol Cell. 2008 Feb;19(2):485-97. doi: 10.1091/mbc.e07-02-0148. Epub 2007 Nov 14. PubMed PMID: 18003982; PubMed Central PMCID: PMC2230580.

51. Rainey-Barger EK, Magnuson B, Tsai B. A chaperone-activated nonenveloped virus perforates the physiologically relevant endoplasmic reticulum membrane. J Virol. 2007 Dec;81(23):12996-3004. doi: 10.1128/JVI.01037-07. Epub 2007 Sep 19. PubMed PMID: 17881435; PubMed Central PMCID: PMC2169125.

52. Rainey-Barger EK, Mkrtchian S, Tsai B. Dimerization of ERp29, a PDI-like protein, is essential for its diverse functions. Mol Biol Cell. 2007 Apr;18(4):1253-60. doi: 10.1091/mbc.e06-11-1004. Epub 2007 Jan 31. PubMed PMID: 17267685; PubMed Central PMCID: PMC1838973.

53. Tsai B. Penetration of nonenveloped viruses into the cytoplasm. Annu Rev Cell Dev Biol. 2007;23:23-43. doi: 10.1146/annurev.cellbio.23.090506.123454. Review. PubMed PMID: 17456018.

54. Forster ML, Sivick K, Park YN, Arvan P, Lencer WI, Tsai B. Protein disulfide isomerase-like proteins play opposing roles during retrotranslocation. J Cell Biol. 2006 Jun 19;173(6):853-9. doi: 10.1083/jcb.200602046. PubMed PMID: 16785320; PubMed Central PMCID: PMC2063911.

55. Low JA, Magnuson B, Tsai B, Imperiale MJ. Identification of gangliosides GD1b and GT1b as receptors for BK virus. J Virol. 2006 Feb;80(3):1361-6. doi: 10.1128/JVI.80.3.1361-1366.2006. PubMed PMID: 16415013; PubMed Central PMCID: PMC1346969.

56. Magnuson B, Rainey EK, Benjamin T, Baryshev M, Mkrtchian S, Tsai B. ERp29 triggers a conformational change in polyomavirus to stimulate membrane binding. Mol Cell. 2005 Oct 28;20(2):289-300. doi: 10.1016/j.molcel.2005.08.034. PubMed PMID: 16246730.

57. Fujinaga Y, Wolf AA, Rodighiero C, Wheeler H, Tsai B, Allen L, Jobling MG, Rapoport T, Holmes RK, Lencer WI. Gangliosides that associate with lipid rafts mediate transport of cholera and related toxins from the plasma membrane to endoplasmic reticulm. Mol Biol Cell. 2003 Dec;14(12):4783-93. doi: 10.1091/mbc.e03-06-0354. Epub 2003 Sep 17. PubMed PMID: 13679513; PubMed Central PMCID: PMC284783.

58. Lencer WI, Tsai B. The intracellular voyage of cholera toxin: going retro. Trends Biochem Sci. 2003 Dec;28(12):639-45. doi: 10.1016/j.tibs.2003.10.002. Review. PubMed PMID: 14659695.

59. Tsai B, Gilbert JM, Stehle T, Lencer W, Benjamin TL, Rapoport TA. Gangliosides are receptors for murine polyoma virus and SV40. EMBO J. 2003 Sep 1;22(17):4346-55. doi: 10.1093/emboj/cdg439. PubMed PMID: 12941687; PubMed Central PMCID: PMC202381.

60. Rodighiero C, Tsai B, Rapoport TA, Lencer WI. Role of ubiquitination in retro-translocation of cholera toxin and escape of cytosolic degradation. EMBO Rep. 2002 Dec;3(12):1222-7. doi: 10.1093/embo-reports/kvf239. Epub 2002 Nov 21. PubMed PMID: 12446567; PubMed Central PMCID: PMC1308323.

61. Tsai B, Rapoport TA. Unfolded cholera toxin is transferred to the ER membrane and released from protein disulfide isomerase upon oxidation by Ero1. J Cell Biol. 2002 Oct 28;159(2):207-16. doi: 10.1083/jcb.200207120. Epub 2002 Oct 28. PubMed PMID: 12403808; PubMed Central PMCID: PMC2173060.

62. Tsai B, Ye Y, Rapoport TA. Retro-translocation of proteins from the endoplasmic reticulum into the cytosol. Nat Rev Mol Cell Biol. 2002 Apr;3(4):246-55. doi: 10.1038/nrm780. Review. PubMed PMID: 11994744.

63. Tsai B, Rodighiero C, Lencer WI, Rapoport TA. Protein disulfide isomerase acts as a redox-dependent chaperone to unfold cholera toxin. Cell. 2001 Mar 23;104(6):937-48. PubMed PMID: 11290330.

64. Tsai W, Morielli AD, Cachero TG, Peralta EG. Receptor protein tyrosine phosphatase alpha participates in the m1 muscarinic acetylcholine receptor-dependent regulation of Kv1.2 channel activity. EMBO J. 1999 Jan 4;18(1):109-18. doi: 10.1093/emboj/18.1.109. PubMed PMID: 9878055; PubMed Central PMCID: PMC1171107.

65. Tsai W, Morielli AD, Peralta EG. The m1 muscarinic acetylcholine receptor transactivates the EGF receptor to modulate ion channel activity. EMBO J. 1997 Aug 1;16(15):4597-605. doi: 10.1093/emboj/16.15.4597. PubMed PMID: 9303304; PubMed Central PMCID: PMC1170086.

66. DeVry CG, Tsai W, Clarke S. Structure of the human gene encoding the protein repair L-isoaspartyl (D-aspartyl) O-methyltransferase. Arch Biochem Biophys. 1996 Nov 15;335(2):321-32. doi: 10.1006/abbi.1996.0513. PubMed PMID: 8914929.

67. Tsai W, Clarke S. Amino acid polymorphisms of the human L-isoaspartyl/D-aspartyl methyltransferase involved in protein repair. Biochem Biophys Res Commun. 1994 Aug 30;203(1):491-7. doi: 10.1006/bbrc.1994.2209. PubMed PMID: 8074695.