Welcome to the Tsai Lab
Viral pathogenesis refers to the molecular mechanism by which different viruses enter host cells in order to cause infection. The viruses that we study include human papillomavirus (HPV), SV40 polyomavirus, SARS-CoV-2, and dengue virus.
Our work in protein homeostasis focuses on understanding endoplasmic reticulum (ER) protein quality control mechanisms. In particular, we’re very interested in understanding how cells detect and resolve the misfolding of secretory proteins, namely proinsulin, and what happens when proinsulin aggregates in the ER.
If you’re curious about our recent work, feel free to check out the Publications section of our site.